Author - Ruslan Dorfman

I have stars in my genome! Or how genetic variations affect your drug response

How drugs affect the body Many commonly used drugs can be helpful for most while causing adverse reactions in others. Medication needs to be absorbed and then metabolized into a biologically active form or inactivated at a certain rate. Drug absorption and secretion (i.e. pharmacokinetics) can be affected by certain [...]

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cardiovascular

Statin adverse side effects vs risk of stroke and heart attack: how to balance the risks?

Statins have long being used for reducing the risk of heart attack and stroke in patients at high risk of cardiovascular disease, particularly in obese and Type 2 Diabetes patients. Clinical trials have demonstrated the positive role of statins in risk reduction that extended well beyond the associated reduction [...]

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pharmacogenetics

Are you Tylenol or Advil person? Alleviating pain through genetics

Chronic pain is not only debilitating and horrible consequence of chronic diseases, trauma, but is also inevitable consequence of medical treatments. Chronic pain is refractory to most of the treatments, but we believe that genetics of pain and pharmacogenetics can substantially improve pain management. In many cases chronic pain arises [...]

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genome sequencing

Should I pay or should I go? Or what do we really know about mutations and disease liability?

Current genome sequencing technologies already allow for cost effective and comprehensive disease prediction. However, for the average consumer, does it really make sense to pay $5,000 for a whole genome analysis at this time? And what can they gain from an analysis of this sort? After all, genome sequencing [...]

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