Your genetics determines the effectiveness of Tecta for youRuslan Dorfman
What is Tecta? How does Tecta work?
Tecta (pantoprazole) is prescribed to treat gastrointestinal ulcers, or for gastroesophageal reflux disease (GERD), which includes heartburn and acid reflux, and reflux esophagitis.
Tecta is part of a family of drugs called Proton Pump Inhibitors (PPIs). These drugs block Proton Pumps, and reduces stomach acidity to prevent ulcers, reflux and GERD.
Aside: Proton pumps are found in the cells lining your stomach and are responsible for secreting stomach acid.
There are many causes of high stomach acidity, some of which you can control such as your lifestyle and diet, and others that are not easily managed, such as your unique genetic makeup and the composition of bacteria in your digestive system (notably Helicobacter pylori/H. pylori).
Is Tecta effective for everyone?
Headaches, dizziness, nausea, stomach pains, gas, diarrhea. These are just some of the side effects you may have experienced if you’ve ever taken Tecta.
While in general Tecta is considered effective, medications are not one-size-fits-all and this can lead to ineffective treatment or adverse side effects. Each of us differs in how our bodies respond to drugs due to individual differences in drug metabolism based on your unique genetics.
A drug response test can determine if Tecta is suitable for you and help to reduce adverse side effects
Your unique genetic composition plays a key role in determining how effective Tecta is for you and how bad your side effects are.
Tecta, as with most other drugs, is metabolized and cleared from your bloodstream by enzymes in your liver. In particular, Tecta is metabolized by the CYP2C19 enzyme (encoded by the Cyp2c19 gene).
If you are experiencing adverse side effects from Tecta, a drug response test will likely show that you carry a cyp2c19 variation that causes you to be a slow metabolizer for tecta. This means that your body is not metabolizing tecta fast enough, causing drug levels in your blood to soar to dangerous levels. In this case, your physician should consider decreasing your dosage.
On the other hand, if Tecta did not relieve your symptoms, there is a good chance that a drug response test will show that you are a fast metabolizer, which means that now your body is metabolizing the drug too quickly, and there’s not enough drug circulating in your bloodstream to relieve GI symptoms. In this case, your physician may consider increasing your Tecta dose or switching your prescription to other PPIs that are less affected by CYP2C19 activity (i.e. lansoprazole and rabeprazole).
The effectiveness of a drug like Tecta for you depends on how your body metabolizes the drug, and this is determined by your individual genetic makeup.
Be educated and proactive about your prescriptions – find out how your body metabolizes drugs!
A drug response test like PillCheckTM is the most effective way for you and your physician to determine how well you will respond to Tecta or other Proton Pump Inhibitor/PPI drugs so that you can avoid adverse side effects or ineffective symptom control.
PillCheckTM will also reveal your drug metabolism profile for many other common prescriptions and can be a powerful tool to help you and your physician improve both safety and effectiveness of your prescription drugs.
Want to learn more?
If you would like to learn more, please read this related blog post: I have stars in my genome! Or how genetic variations affect your drug response.
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